Senior Scientist

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as
Science
magazine's No. 1 Top Employer for four consecutive years, certification as a Great Place to Work in the U.S., and a place on
The Sunday Times
Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About The Role
The Senior Scientist will work within a multidisciplinary team of scientists focused on the design, engineering, and preclinical characterization of ground-breaking biotherapeutics. Specifically, the candidate will help lead engineering and optimization campaigns for a diverse array of biomolecular scaffolds including binding and targeting moieties, signaling molecules, enzymes, and biological drug delivery platforms.

What You'll Do

• Drive biomolecular engineering efforts within Insmed research projects, including strategy and methods development.
• Construct recombinant systems encoding protein variants and combinatorial protein libraries.
• Conceptualize, construct, qualify, and implement high throughput screening platforms to enable candidate selection from large panels and/or combinatorial libraries of engineered protein variants.
• Conduct precision protein engineering to achieve specified design objectives, working both independently and in collaboration with computational biologists.
• Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs.
• Develop, qualify, and deploy quantitative functional assays to characterize protein performance in vitro.
• Assess therapeutic candidate performance using in vivo models.
• Contribute to collaborative prioritization and decision making on prospective discovery and development programs.
• Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis.
• Participate in cross-disciplinary mentoring and training within the RDL NH team.
• Present scientific results to the RDL NH team, Insmed research department, and external scientific community, as needed.
• Assist with coordination and day-to-day management of RDL NH site operations.

Who You Are

• Minimum PhD and 5+ years experience OR MS and 9+ years' experience in biochemistry, molecular biology, bioengineering, or related field.

Knowledge & Experience

• Deep technical understanding of, and hands-on experience with, molecular biology, recombinant DNA technology, protein mutagenesis, and protein biochemistry.
• Expertise with recombinant protein expression and purification.
• Expertise with routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, ELISA.
• Experience with protein-protein binding analysis a must, and experience with enzyme analysis a plus.
• Proven track record in experimental methods development, including experimental design, execution, and evaluation.
• Experience in high throughput functional screen development for protein libraries strongly preferred.
• Experience with lab automation strongly preferred.
• Experience with next-generation sequencing strongly preferred.

Skills

• PCR, molecular cloning, Cell culture (microbial and tissue culture), protein chromatography, BLI/SPR, ELISA, enzyme kinetics, electrophoresis, flow cytometry, spectroscopy, fluorimetry, etc.
• Must have excellent communication skills (verbal and written).
• Highly organized with a strong attention to detail and conciseness.
• Strong analytical and problem-solving skills.
• Broad knowledge of scientific principles and concepts.

Pay Range
$104, ,800.00 Annual

Life at Insmed
At Insmed, you'll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights Of Our U.S. Offerings Include

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

*Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at

and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.*